Multicentre, cross-sectional surveillance of Helicobacter pylori prevalence and antibiotic resistance to clarithromycin and levofloxacin in urban China using the string test coupled with quantitative PCR.
Abstract
Antibiotic-resistant Helicobacter pylori infections pose a considerable burden on health care in China.1 However, the existing knowledge of H pylori prevalence and antibiotic resistance in urban China is derived from heterogeneous testing methodologies and studied populations.2 The string test is a minimally invasive method used to obtain gastric fluid samples3,4 and can be used to detect H pylori infection and antibiotic resistance when combined with quantitative PCR (appendix p 3–4).5 We conducted nationwide, multicentre, cross-sectional surveillance using this combined diagnostic approach to provide an overview of H pylori prevalence and antibiotic resistance rates, specifically against clarithromycin and levofloxacin, in urban China.
How strong is the evidence?
Evidence Hub reads this as a cross-sectional. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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