Efficacy of phage therapy in Diabetic Foot Ulcers (DFUs): a systematic review
Abstract
Background: Diabetic foot ulcers (DFUs) are a severe complication of diabetes, often leading to infections caused by multidrug-resistant (MDR) bacteria, which complicate treatment and increase amputation risks. Bacteriophage (phage) therapy, targeting specific bacterial pathogens, has re-emerged as a promising alternative to antibiotics. This systematic review evaluates the efficacy of phage therapy for DFUs.
Methods: A comprehensive search was conducted in PubMed, Scopus, Web of Science, and Embase up to October 29, 2024, using keywords such as "phage therapy," "diabetic foot ulcers," and "bacteriophages." Included were original English-language studies investigating phage therapy for DFUs, while reviews and non-English articles were excluded. Data extraction and quality assessment were performed independently by two reviewers.
Results: Twenty-one studies demonstrated phage therapy's effectiveness against key DFU pathogens, including Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, and Klebsiella pneumoniae. Phage cocktails showed superior efficacy in preventing bacterial regrowth and overcoming resistance compared to single phages. Synergistic effects with antibiotics (e.g., ciprofloxacin) were observed, enhancing biofilm penetration and bacterial eradication. Case studies reported high tolerability and clinical resolution, even in antibiotic-resistant infections. However, evidence remains limited to small-scale studies.
Conclusion: Phage therapy is a…
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Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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