Infection rates following custom-made cranioplasty using heterologous materials: insights from a systematic review on 3260 patients with a focus on follow-up length
Abstract
Custom-made cranioplasty can be performed using various heterologous materials, each associated with a distinct complication profile. This systematic review focuses on infections, the most common complication following cranioplasty. A systematic review of the available literature was conducted to identify infection and explantation rates associated with materials used in custom-made heterologous cranioplasty. A comprehensive search of PubMed/MEDLINE, Scopus, and Embase databases yielded 3437 articles. After screening, 43 articles met the inclusion criteria and data on study parameters, patient populations, and infection characteristics were extracted. Forty-three articles were selected and included in this review, analyzing a total of 3260 implanted cranioplasties, divided by material as follows: 931 titanium, 1227 hydroxyapatite, 680 PMMA, 379 PEEK, and 143 composites. The cumulative infection and explantation rates were: 8.2% and 3.7% for titanium, 6.7% and 5.3% for hydroxyapatite, 14.9% and 6.1% for PMMA, 11.1% and 3.8% for PEEK, and 4.2% and 6.2% for composites. Importantly, the follow-up duration varied significantly among materials. Studies involving titanium and composites had the shortest follow-up, potentially underestimating infection rates, while studies on PMMA and hydroxyapatite had the longest follow-up, providing more robust estimates. This review confirms general trends in infection rates among cranioplasty materials and emphasizes the critical role of…
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