Examining the Effectiveness of Neuropsychological Interventions on Cognition in Patients with Epilepsy: A Systematic Review and Meta-Analysis
Abstract
This meta-analysis evaluated the effectiveness of neuropsychological interventions in enhancing cognition in patients with epilepsy. The systematic review was conducted under PRISMA guidelines. Of 1363 articles, 25 met the inclusion criteria. Meta-analyses assessing pre-post changes in experimental interventions (i.e., without comparison to control groups) revealed moderate effects on cognition in adults (g = 0.29; 95% CI = 0.18, 0.40; p < 0.0001), with significant effects for attention (g = 0.24; 95% CI = 0.06, 0.43; p = 0.0098), immediate memory (g = 0.34; 95% CI = 0.21, 0.47; p < 0.0001), delayed memory (g = 0.38; 95% CI = 0.18, 0.57; p < 0.0001), and language (g = 0.33; 95% CI = 0.06, 0.59; p = 0.0159). In pediatric samples, moderate effects were found on overall cognition (g = 0.55; 95% CI = 0.22, 0.89; p = 0.0012), with gains in attention (g = 0.66; 95% CI = 0.15, 1.17; p = 0.01) and working memory (g = 0.80; 95% CI = -0.05, 1.65; p = 0.06). Comparisons with control groups (i.e., patients without intervention) showed a trend towards positive effects in adults (g = 0.35; 95% CI = -0.00, 0.71; p = 0.053), with brain training games associated with poorer outcomes (B = -1.03; SE = 0.52; 95% CI = -2.05, -0.00; p = 0.049). No significant differences were found in pediatric samples (g = 0.34; 95% CI = -0.22, 0.89; p = 0.24). The findings support the implementation of targeted cognitive interventions in clinical practice, offering evidence-based recommendations.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.