Impact of cycling exercise in patients with chronic kidney disease: protocol for a systematic review and trial sequential meta-analysis
Abstract
Chronic kidney disease is a global public health problem affecting approximately 10% of the adult population. Conventional management combines pharmacotherapy and dialysis, yet long-term complications persist. Cycling, a low joint load exercise, may improve cardiopulmonary function and renal outcomes, but conflicting evidence exists regarding its efficacy in advanced CKD. Randomized controlled trials (RCTs) that compare cycling exercise and usual care in patients with chronic kidney disease will be included. Literature searches will be conducted in PubMed, Web of Science, Embase, and Cochrane Library. Two reviewers will independently perform the processes of literature retrieval, screening, data extraction, and assessment of risk of bias. Risk of bias in included studies will be evaluated using Revised Cochrane risk-of-bias tool (ROB 2) for RCTs. Review Manager (RevMan) will be used for data pooling. Subgroup analysis, trial sequential analysis (TSA), and sensitivity analysis will be conducted. Ethical approval is not required because this study is a secondary analysis of existing data. We will disseminate the findings through peer-reviewed publications. PROSPERO CRD420251048364.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.