SARC-Calf using calf circumference adjusted for BMI predicts six-months readmission and mortality in hospitalized patients: a secondary analysis of a cohort study
Abstract
BACKGROUND
Sarcopenia is a prevalent condition associated with worse clinical outcomes in hospitalized patients. The SARC-Calf is an accurate instrument for its screening; however, it includes the calf circumference (CC) measure as a criterion, which is influenced by adiposity. An adjustment for CC based on body mass index (BMI) has been proposed, but the literature lacks studies evaluating the SARC-Calf using adjusted CC.
OBJECTIVE
This study aimed to evaluate the prognostic value of the SARC-Calf with BMI-adjusted CC and compare it between adult and older hospitalized patients.
METHODS
This is a secondary analysis of a cohort with prospective data collection, including individuals aged ≥18 years, lucid and able to communicate. SARC-Calf was applied using BMI-adjusted CC, obtained by subtracting 3, 7, and 12 cm from CC values when BMI was 25-29.99, 30-39.99, and ≥ 40kg/m2, respectively. Outcomes of interest included prolonged hospital stay, in-hospital death, hospital readmission, and mortality six months after discharge. Logistic and Cox regression analyses, adjusted for Charlson comorbidity index and sex, were performed.
RESULTS
We analyzed data from 554 patients (mean age 55.2±14.9 years, 52.9% males). Suggestive signs of sarcopenia by SARC-Calf with BMI-adjusted CC were identified in 40.4% of patients (38.6% in adults and 42.7% in older patients, p=0.380). Suggestive signs of sarcopenia were associated with hospital readmission in adults (OR=1.8; 95%CI 1.1, 2.9), and…
How strong is the evidence?
Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 554 participants or records.
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