Drug management of TB in the intensive care setting: an international multicentre study
Abstract
BACKGROUNDIndividuals requiring admission to an intensive care unit (ICU) due to TB have complex clinical presentations and high mortality rates. There is a clear knowledge gap on how to optimally manage treatment.OBJECTIVETo evaluate the treatment outcomes of TB patients in ICU and explore the potential benefits of intravenous (IV) TB treatment regimens.METHODSA retrospective observational multicentre study was conducted by the International Severe TB and Rehabilitation Working Group of the Global Tuberculosis Network (GTN). The study included TB patients aged >15 years admitted to ICUs in Europe, Asia and Latin America from January 1, 2005 to December 31, 2018. Data on demographics, microbiology, clinical information and treatment outcomes were collected and analysed.RESULTSThe study enrolled 434 cases. Over half were sputum smear-positive and 85.7% were culture-positive. Most required invasive mechanical ventilation, vasopressor support and steroids. Only 48.4% had TB medications initiated before or during ICU admission. The overall mortality rate was 54.8%, with 33.4% achieving treatment success. IV anti-TB drugs were administered to 43% of participants, with levofloxacin and amikacin being the most used. IV treatment longer than 10 days was associated with better outcomes. Individuals receiving IV rifampicin had a lower mortality rate (35.7%) compared to those who did not receive it (51.7%), p-value= 0.05.CONCLUSIONSHigh mortality rates in ICU indicate the need for…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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