Serotype and antimicrobial susceptibility patterns of Vibrio cholerae in cholera outbreak areas of East and Central Oromia Region, Ethiopia, 2024
Abstract
INTRODUCTION: Cholera is an acute diarrheal infection caused by the consumption of food or water contaminated with Vibrio cholerae serotypes Ogawa and Inaba. Historically, Vibrio cholerae has remained susceptible to several key antibiotics. However, resistance to older antibiotics has been increasingly reported worldwide. The objective of this study was to assess the distribution of Vibrio cholerae serotypes and their susceptibility patterns in the cholera outbreak areas of the East and central Oromia region, Ethiopia, 2024.
METHOD: The study was conducted on isolates recovered from stool specimens collected from Cholera Outbreak areas of East and Central Oromia Region in 2024. The study design used was a laboratory-based retrospective cross-sectional study. Serotyping and antimicrobial susceptibility testing were performed on isolates identified after enrichment in alkaline peptone water, (BIOMARK Laboratories, India). Presumptive screening of the isolates was performed using the Oxidase test (HiMedia, India), string test (Liofilchem, Italy), and other standard biochemical tests. Presumptive identification with O1 and O139 antisera (Hardy Diagnostics, USA) was carried out using the slide agglutination method with polyvalent O1 or O139 antisera. Antimicrobial susceptibility patterns were assessed using the disk diffusion method.
RESULTS: All isolates tested for identification of Vibrio cholerae suspects were found to be serogroup O1. Of these Ogawa accounts for 62% and Inaba…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.