Antibiotic use among patients with acute exacerbation of COPD in Pulmonary Diseases University Clinical Hospital from North-Eastern Romania
Abstract
(Abstract): Aims: Acute exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) need sometimes hospitalizations and requires five to seven days of oral antibiotics, according to GOLD recommendations. The aim of our study was to find out the most common used antibiotics in patients with AECOPD admitted in a University Clinical Hospital of Pulmonary Diseases from North-Eastern Romania, from June 2014 to May 2019. Materials and methods: A descriptive cross-sectional, single-center, retrospective study, conducted among 460 admissions in hospital with J44.0 (COPD with lower airway acute infection) and J44.1 (COPD with acute, nonspecific exacerbation) diagnostics. Results: The majority (354; 77%) of admissions were for male; average age was 66 ± 9 years. The preferred antibiotic for first use was ceftriaxone (51%), but the patients were treated also with ciprofloxacin (13%), levofloxacin (12%), ceftazidime, amoxicillin + clavulanic acid or other antibiotics according to antibiograms, with a medium of 10 days treatment. Most of the patients received one antibiotic during hospitalization, 23.9% received two antibiotics and 7.6% of patients received 3 antibiotics. Hospitalization average length was 11 ± 5 days. Conclusions: Ceftriaxone was the preferred drug for acute COPD exacerbation treatment for hospitalized patients, while the average hospital length in our study was 11 days.
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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