Patients’ acceptability, adherence and satisfaction on the modified shorter all-oral multidrug-resistant tuberculosis regimen: a two-phase cross-sectional study in Tanzania
Abstract
Objectives To determine patients’ acceptability, satisfaction and adherence to shorter all-oral multidrug-resistant tuberculosis (MDR-TB) regimen in Tanzania. Design A two-phase cross-sectional study with data collected within 6 months of Removed Injectable modified Short-course regimens for EXpert MDR-TB (RISE) study implementation and the second phase within 15 months of implementation using the same reference populations. Settings 18 health facilities across eight regions of Tanzania. Participants Rifampicin-resistant TB/MDR-TB patients enrolled in the RISE study. Outcome measures We assessed patients’ acceptability, adherence and satisfaction with the regimen using an interval scale structured questionnaire. Results The majority of the patients found the shorter oral MDR-TB treatment acceptable, adhered to it well and were generally satisfied. The median score (IQR) for acceptability was 1.7 (1.03–2.00) but it ranged between 1.3 (1.3–2) and 1.7 (1–1.79) for the first and second phases, respectively. Regarding adherence, the median score (IQR) stood at 4 (3.67–4.67) with scores significantly higher in the second phase at 4.33 (4.00–5.007) compared with the first at 4.67 (4.00–5.0), p value=0.01. The overall satisfaction was high at 1.5 (1.33−1.78) but it ranged between 1.22 (1.00–1.78) and 1.42 (1.11–1.78) for the first and second phases, respectively. Worrying about side effects was statistically associated with adherence (p value<0.05). No statistically significant…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.