Endoscopic-Assisted Excision of Parotid Castleman Disease in Pediatric Patients: A Case Series of Three Patients and a Literature Review
Abstract
Case series Patients: Female, 2-year-old • Male, 7-year-old • Male, 10-year-old Final Diagnosis: Unicentric Castleman’s disease Symptoms: Asymptomatic • mass in paroid gland Clinical Procedure: Endoscopy • surgery Specialty: Pediatrics and Neonatology Objective: Rare disease Background Castleman disease (CD) is a rare lymphoproliferative disorder, and parotid involvement in children is exceptionally uncommon. It is typically classified as unicentric (UCD) or multicentric; the hyaline vascular (HV) type is most prevalent. Surgical excision remains the standard curative treatment for UCD. Case Reports This study synthesizes recent advances in endoscopic-assisted excision of parotid CD among pediatric patients. We describe 3 pediatric patients (ages 2, 7, and 10 years) who presented with asymptomatic parotid masses, all initially misdiagnosed. Each patient underwent endoscopic-assisted resection via retroauricular or postauricular incisions to minimize visible scarring. Histopathologic evaluation confirmed HV-type UCD in all cases. No facial nerve injury occurred; all patients achieved uneventful recovery with no recurrence and excellent cosmetic results. A literature review of PubMed and Web of Science covering January 2000 to July 2025 identified 32 cases of parotid CD from 27 articles. HV-type UCD was predominant; 13 (40.6%) were pediatric cases, typically involving slow-growing, asymptomatic masses. Surgical excision was curative; conventional approaches often resulted in…
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