Total Knee Arthroplasty for Secondary Osteoarthritis in Patients With Multiple Hereditary Exostoses: A Case Series
Abstract
Case series Patients: Female, 66-year-old • Male, 66-year-old • Female, 72-year-old Final Diagnosis: Secondary osteoarthritis in patients with multiple hereditary exostose Symptoms: Knee pain • deformity • limited range of motion Clinical Procedure: — Specialty: Orthopedics and Traumatology Objective: Rare disease Background Multiple hereditary exostoses (MHE) is a rare genetic disorder characterized by multiple osteochondromas, often leading to joint deformity and early-onset osteoarthritis (OA). The knee is one of the most commonly affected joints, and progressive deformity and malalignment may eventually require surgical intervention. Total knee arthroplasty (TKA) in patients with MHE remains technically demanding because of distorted joint anatomy and soft tissue imbalance. Because of the rarity of this condition, published reports describing surgical strategies and clinical and radiographic outcomes of TKA in patients with MHE remain limited. Case Reports We report 4 cases of MHE treated with TKA for advanced OA. Preoperative evaluation demonstrated varus or valgus deformities and limited range of motion in all cases. In all cases, TKA was performed using the measured resection technique. Two cases required constrained prostheses due to soft tissue imbalance. In 1 patient with a history of femoral fracture fixation and an obstructed femoral canal, portable navigation was employed to facilitate accurate bone resection. All patients achieved pain relief, with improved…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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