Electrocardiographic and Arrhythmic Manifestations of End-Stage Atrial Myopathy in Patients With Longstanding Persistent or Permanent Atrial Fibrillation: A 3-Patient Case Series
Abstract
Case series Patients: Male, 45-year-old • Male, 42-year-old • Female, 69-year-old Final Diagnosis: End stage atrial myopathy Symptoms: Arrhythmia • atrial fibrillation Clinical Procedure: — Specialty: Cardiology Objective: Unusual clinical course Background Advanced atrial remodeling, often associated with atrial fibrosis, may be accompanied by severe atrial electrical dysfunction and a range of electrocardiographic and arrhythmic manifestations. Data on the clinical features of this process are limited. Case Reports We report 3 patients with end-stage atrial myopathy and longstanding persistent or permanent atrial fibrillation (AF). One patient with extensive biatrial scar developed recurrent low-amplitude atrial tachycardias after AF ablation. Two patients demonstrated progression from AF to atrial standstill with junctional rhythms. In both patients, serial ECGs showed loss of fibrillatory activity, and device interrogation demonstrated absent atrial sensing and capture. One patient underwent pacemaker implantation without atrial lead placement, due to the absence of atrial sensing or capture on electrophysiology mapping. Important coexisting substrates for atrial remodeling included hypertrophic cardiomyopathy, mitral valve disease, and prior cardiac surgeries. Conclusions Patients with longstanding persistent or permanent AF may demonstrate distinct findings suggestive of advanced atrial myopathy, including loss of fibrillatory waves on ECG, low-amplitude atrial…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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