Complicated cataract in young hemophilia B patients: A case series
Abstract
Cataract formation in young individuals is uncommon and often prompts evaluation for underlying systemic or metabolic disorders. Haemophilia B, a rare X-linked recessive coagulation disorder caused by Factor IX deficiency, is primarily characterized by bleeding manifestations, with ocular involvement being infrequently reported. This case series describes three young male patients with known haemophilia B on long-term desmopressin therapy who presented with bilateral visual impairment and were found to have early-onset cataracts. The patients, aged 18, 30, and 44 years, demonstrated varying lenticular changes, including bilateral complicated cataracts and posterior subcapsular cataracts, with best-corrected visual acuity ranging from 3/60 to 6/60. Two patients exhibited iron deficiency anaemia and coagulation abnormalities, while one had normal activated partial thromboplastin time at presentation. Comprehensive ophthalmologic evaluation confirmed cataractous changes, and two patients successfully underwent phacoemulsification under perioperative Factor IX replacement with uneventful surgical outcomes and significant postoperative visual improvement. The third patient was advised to have surgery but was lost to follow-up. This series highlights the challenges of cataract management in haemophilia, emphasizing the importance of meticulous perioperative planning, multidisciplinary coordination, and adequate coagulation factor coverage to minimize intraocular bleeding risk. The…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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