Sepsis secondary to postoperative Enterococcus gallinarum infection in a patient with rectal cancer: A case report
Abstract
RATIONALE: Enterococcus gallinarum, while of relatively low virulence, is an emerging multidrug-resistant opportunistic pathogen. This case report aims to highlight the diagnostic and therapeutic challenges posed by this organism, particularly in immunocompromised hosts following major surgery, and to emphasize the importance of early microbiological identification and targeted therapy in such scenarios.
PATIENT CONCERNS: A 55-year-old woman was admitted to our hospital with a 1-month history of recurrent abdominal pain and bloating. She underwent surgical intervention and subsequently developed septic shock. Despite empiric therapy with imipenem-cilastatin (1000 mg every 8 hours) plus vancomycin (1000 mg every 12 hours), her condition deteriorated, presenting with persistent fever and progressive multiorgan dysfunction syndrome.
DIAGNOSES: Enterococcus gallinarum (Group D), intrinsically resistant to vancomycin, was isolated from the wound secretion culture.
INTERVENTIONS: According to the culture results, antibiotic therapy was adjusted to levofloxacin (300 mg once daily) plus meropenem (1000 mg every 8 hours).
OUTCOMES: After the adjustment of antibiotics, the patient's body temperature normalized within days. Following 1 week of targeted antibiotic therapy, all infection markers (including white blood cell count and procalcitonin) normalized. The antibiotic regimen was successfully de-escalated, and the patient was discharged after full clinical recovery.
LESSONS: The…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.