Device-associated Mycobacterium mageritense Bloodstream Infection in a Breast Cancer Patient: A Case Emphasizing Diagnostic Accuracy and Tailored Therapeutic Strategy
Abstract
Nontuberculous mycobacteria (NTM) have become increasingly recognized as clinically significant pathogens, especially in immunocompromised patients with indwelling devices like chemoports. This report presents the case of a 71-year-old woman with a history of breast cancer, who developed a persistent, unexplained fever lasting 6 weeks after completing chemotherapy with trastuzumab and pertuzumab. Despite broad-spectrum antibiotic therapy, the fever persisted, and diagnostic workup revealed an infection by
Mycobacterium mageritense
, a rapidly growing NTM, linked to her chemoport, which had been in place for 7 months. Initial empirical treatment with meropenem and teicoplanin was administered, but on confirmation of NTM, therapy transitioned to targeted antibiotics, including amikacin and levofloxacin. Surgical removal of the chemoport was performed. Posttreatment, the patient showed clinical improvement with resolution of fever and normalization of laboratory parameters.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.