A Successful Management of Concurrent Infection with Cranial Nocardia gipuzkoensis and Pulmonary Klebsiella pneumoniae: A Case Report
Abstract
Introduction: Successful management of concurrent infection with cranial Nocardia gipuzkoensis and pulmonary Klebsiella pneumoniae has never been previously described. Case Presentation: A 71-year-old female was referred to our hospital due to an intracranial space-occupying lesion persisting for over 20 days. Her initial chief complaints suggested cranial and pulmonary inflammation. Subsequently, drainage of the brain lesion was performed, and N. gipuzkoensis infection was confirmed through microbial culture and metagenomic next-generation sequencing (mNGS). Sputum culture identified K. pneumoniae infection. Based on antimicrobial susceptibility test results and allergic history, the patient showed improvement after two weeks of intravenous meropenem (2 g/8 h) combined with vancomycin (1 g/12 h). Neurological recovery was achieved, followed by over six weeks of oral Linezolid (0.6 g/12 h) and Levofloxacin (0.5 g/24 h). Conclusions: This case reports the successful management of concurrent infections, providing supporting evidence for the potential to shorten intravenous administration in nocardiosis treatment.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.