Regular collagen peptide administration exerts anti-obesity effects in high-caloric diet-fed rodents—a systematic review with meta-analysis of animal trials
Abstract
Cost-effective and easy-to-implement nutritional approaches to overcoming obesity and accompanying diseases remain of considerable therapeutic interest. Collagen peptides (CP) have previously demonstrated potential to alleviate obesity and related symptoms during high-fat/ high-caloric diets. Therefore, a systematic review and meta-analysis have been conducted to pool the evidence from the last decades. A systematic literature search was conducted in accordance with the PRISMA statement in PubMed, Scopus, CINAHL, MEDLINE and ScienceDirect in March 2024. Risk of bias was assessed using the SYRCLE tool for animal studies. A random-effects model with standardized mean differences (SMD) calculated overall effect sizes. Preclinical controlled trials as well as randomized controlled trials were eligible if rodents received a high-fat or high-caloric diet, were genetically not modified and administered CPs compared to a placebo for at least 3 weeks. Twenty-one and nineteen (n = 339) studies were included in the systematic review and meta-analysis, respectively. A several-week CP supplementation led to significant decreases in body mass (p < 0.01; SMD = −1.87), food intake (p = 0.01; SMD = −1.43), glucose metabolism (p < 0.02; SMD = −2.21), adipose tissue & organ content (p < 0.01; SMD = −1.26), LDL (p < 0.01; SMD = −2.02), triacylglycerol (p < 0.01; SMD = −2.16) and leptin (p = 0.01; SMD = −1.33). Significant increases were observed in HDL (p = 0.04; SMD = 1.14) and adiponectin (p…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 339 participants or records.
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