Investigating alginate and chitosan electrospun nanofibers as a potential wound dressing: an in vitro study
Abstract
The research project focuses on conducting an in vitro comparison between sodium alginate and chitosan electrospun nanofibers for moist wound management. These fabricated nanofibers were incorporated with levofloxacin (Lev) as a model drug to investigate their release behavior. The study included a comprehensive examination of the physicochemical, thermal, antibacterial, and cytocompatibility properties of these nanofibers. Both sodium alginate (SA-L) and chitosan (CS-L) nanofibers were successfully produced with a homogeneous and defect-free structure. XRD and FTIR analyses were conducted to validate the incorporation of Lev in the nanofibers. In terms of liquid absorption capacity, it was observed that sodium alginate nanofibers outperformed chitosan nanofibers, exhibiting absorption capacities of 5.9, 5.88, and 7.1 g/g for PBS, solution A, and DI, respectively, for SA-L, compared to 5.27, 4.42, and 5.3 g/g for CS-L nanofibers. This superior absorption ability in SA-L nanofibers may be attributed to the inherent gel-forming properties of alginate in aqueous environments. Furthermore, the release kinetics indicated that SA-L nanofibers exhibited faster drug release compared to CS-L nanofibers, which could be attributed to alginate’s natural gel-forming tendency in aqueous mediums. Both SA-L and CS-L nanofibers demonstrated remarkable efficacy against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa), with CS-L nanofibers displaying larger…
How strong is the evidence?
Evidence Hub reads this as a experimental / empirical study, done in cell cultures (in vitro), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.