Exploring Resistance of Fluoroquinolones in Uropathogenic E. Coli and Optimized Lead Prediction Through In-Silico
Abstract
Fluoroquinolone resistance in uropathogenic Escherichia coli (UPEC) poses a significant challenge in the treatment of urinary tract infections (UTIs), a major global health issue. As resistance rates rise, particularly in developing countries, there is an urgent need for novel derivatives. This study aims to explore fluoroquinolone resistance in UPEC isolates and identify potential lead compounds using in-silico methods to optimize fluoroquinolone derivatives that may overcome resistance. A retr
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