Effect of intralesional levofloxacin in the treatment of cutaneous leishmaniasis
Abstract
Background: People living in some areas are more susceptible to having cutaneous leishmaniasis (CL), yet this illness is observed throughout the world.Skin ulcers are found to be the hallmark of CL, which are most likely caused by the immune system's attempts to suppress the proliferation of Leishmania parasites.Objective: To investigate the effectiveness of intralesional levofloxacin in localized CL treatment.Methods: A cohort study was conducted from November 2021 to March 2022 at dermatologist clinic in Badrah district of Wasit province, in the east of Iraq.Fifty male and female patients age ranging from 8 to 34 (median ± SD; 20 ± 6.58) with localized CL enrolled in the study.The diagnosis of localized CL was performed at the clinic.For every 1 cm diameter, an average dose of 1 mL of Levofloxacin solution was administered subcutaneously to all the patients for 3-5 times every 5 days during the treatment period (median ± SD; 4 ± 0.74).Results: It was observed that 45 out of 50 patients who received the intralesional levofloxacin showed a positive response toward the treatment and were completely cured (with a cure rate of 90%).The diameters Effect of intralesional levofloxacin in leishmaniasis treatment e93
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 50 participants or records.
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