Formulation and in-vitro evaluation of levofloxacin tablets by using different superdisintegrants
Abstract
Levofloxacin is a synthetic third generation flouroquinolones antibacterial agent with a broad spectrum of activity against Gram-positive and Gram-negative aerobic bacteria, atypical respiratory pathogens and some anaerobes. The present work was aimed to formulation development, in-vitro evaluation and comparative study of the effect of different types of superdisintegrants on disintegration time and in-vitro dissolution of Levofloxacin 250 mg tablets for the potential use of the drug for its therapeutic effect. Levofloxacin oral formulations were prepared with different super disintegrants. The superintegrants were sodium starch glycolate (SSG), crosspovidone (XL-10) and crosscarmellose sodium (CCS) used in the preparation of Levofloxacin oral formulations. The formulations were coded as F1 (Cross povidone), F2 (crosscarmellose sodium) and F3 (sodium starch glycolate). The Levofloxacin oral formulation (F2) with crosscarmellose sodium has shown the better disintegration time and increases the dissolution rate when compared to the other super disintegrants.
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