In vitro activities of levofloxacin in combination with fosfomycin against staphylococcus aureus
Abstract
AIM:To investigate the in vitro bactericidal activity of levofloxacin alone and combined with fosfomycin against 3 strains MSSA and 1 stain MRSA. METHODS:Three MSSA strains and 1 MRSA from clinical specimens were used in this study.Time-kill curve method was carried out with different concentration of the two drugs both alone and in combination.RESULTS:Levoloxacin alone showed a concentration-dependent time-kill curve against three strains of MSSA,fosfomycin showed a nonconcentration-dependent time-kill curve.Neither levofloxacin nor fosfomycin alone inhibited bacterial growth at 1/4 MIC;but the combination of this two drugs at 1/4 the respective MIC showed a synergistic bactericidal effect,a 2-3 log10 decrease with respect to the most active antibiotic alone.CONCLUSION:The combination of subinhibitory concentrations of levofloxacin and fosfomycin presented synergism,exerting a bactericidal effect.The combination also has a bactericidal effect against MRSA.
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