Study on in vitro release rate of Levofloxacin Hydrochloride Gel
Abstract
Objective:To study in vitro release rate of Levofloxacin Hydrochloride Gel.Methods:Levofloxacin Hydrochloride in the releasing mediator were determined by HPLC, and the drug releasing characteristics of Levofloxacin Hy drochloride Gel and Levofloxacin Hydrochloride ointment were studied by bag filter method. Results:Levofloxacin Hydrochloride Gel can release within 36 hours, Weibull distributing modle is the best simulation for in vitro release. Com paring with Levofloxacin Hydrochloride ointment, Levofloxacin Hydrochloride Gel release quickly and completely. Conclusion:The Levofloxacin Hydrochloride Gel is able to release rapidly, and the method is convenient, stabilize and reliable.
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