In vitro study of the biological activity of complex compounds synthesized based on levofloxacin
Abstract
This study investigates the antibacterial activity of novel metal complexes synthesizedusing levofloxacin (LEV) as a ligand. The in vitro antimicrobial effects of these complexes wereevaluated against three clinically significant bacterial strains: Bacillus subtilis, Escherichia coli,and Pseudomonas aeruginosa. The synthesized copper(II), cobalt(II), and nickel(II) complexes oflevofloxacin were tested using the agar well diffusion method at a fixed concentration of 35µg/mL. The diameter of the bacterial growth inhibition zones was measured and compared to thoseproduced by free levofloxacin and the corresponding metal salts. Results demonstrated that themetal complexes exhibited significantly enhanced antibacterial activity compared to levofloxacinalone, with the copper complex showing the highest efficacy. These findings suggest that metalcomplexation with levofloxacin can improve its antimicrobial potency and may serve as apromising strategy for developing more effective antibacterial agents..
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