Additional file 3: of In silico trials using Monte Carlo simulation to evaluate ciprofloxacin and levofloxacin dosing in critically ill patients receiving prolonged intermittent renal replacement therapy
Abstract
Probability of target attainment of fluoroquinolones at different MICs in virtual patients with different PIRRT settings. The figures illustrate probability of target attainment (PTA) of selected fluoroquinolone regimens at different MICs in virtual patients with other PIRRT settings that are not included in the main manuscript. The other PIRRT settings include 8-h hemofiltration with an ultrafiltrate flow rate of 5 L/h, 10-h hemodialysis with a dialysate flow rate of 4 L/h, and 10-h hemofiltration with an ultrafiltrate flow rate of 4 L/h. The first three figures describe PTA of selected ciprofloxacin and levofloxacin dosing regimens at different MICs for Gram-negative infection with P. aeruginosa in virtual patients, while the last figure depicts PTA of selected levofloxacin dosing regimens for Gram-positive infections with S. pneumoniae. (PDF 214 kb)
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