Additional file 2: of In silico trials using Monte Carlo simulation to evaluate ciprofloxacin and levofloxacin dosing in critically ill patients receiving prolonged intermittent renal replacement therapy
Abstract
Probability of target attainment of fluoroquinolones in virtual patients with different PIRRT settings. The tables report probability of target attainment (PTA) of selected fluoroquinolone regimens in virtual patients with other PIRRT settings that are not included in the main text. The other PIRRT settings include 8-h hemofiltration with an ultrafiltrate flow rate of 5 L/h, 10-h hemodialysis with a dialysate flow rate of 4 L/h, and 10-h hemofiltration with an ultrafiltrate flow rate of 4 L/h. The first three tables describe PTA of selected ciprofloxacin and levofloxacin dosing regimens for Gram-negative infection with P. aeruginosa in virtual patients, while the other three tables illustrate PTA of selected levofloxacin dosing regimens for Gram-positive infections with S. pneumoniae. (PDF 235 kb)
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.