Molecular Docking and Binding Mechanism Analysis of Levofloxacin Structural Derivatives with DNA Gyrase and Topoisomerase IV
Abstract
Persistent microbial antibiotic resistance, together with the growing frequency of pandemics, fuels the demand for new antimicrobial agents (AntAg). Given the AntAg shortfall, studies aimed at developing rapid strategies for identifying novel drug candidates are highly relevant. The present investigation is designed to carry out an in silico examination of the biological activity spectrum along with the molecular binding interactions of four structurally distinct levofloxacin (Lvf) variants enga
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