Analysis of risk factors FOT QTC interval prolongation in COVID-19 patients: the role of creatinine level, heart failure, hypertension and levofloxacin therapy
Abstract
Objective: QT prolongation is directly related to the risk of ventricular arrhythmias and sudden cardiac death. Age, the presence of comorbidities and the treatment used have proven effects on QT prolongation and also the main influence on the course of SARS-CoV2 infection. Fluoroquinolines are well known for their impact to prolong QT interval. The risk of dangerous ventricular arrhythmias was also reported in patients with acute infectious disease, which was associated with high levels of IL-6 (interleukin-6). The primary objective of the study was to identify and evaluate the sociodemographic and clinical parameters associated with QTc prolongation in hospitalized patients with COVID-19.Design and method: The medical records of 93 patients hospitalized for COVID-19 infection were retrospectively analyzed, considering the presence of such a disease as hypertension, diabetes, atrial fibrillation, heart failure and levofloxacin treatment. The study population was divided according to the levofloxacin receiving into two groups. A 12-lead ECG was performed in each patient, from which the QTc interval was calculated (Bazzet formula). Selected parameters were then statistically analysed, with an emphasis on their effect on the corrected QTc interval. Results: Creatinine level was associated with QTc prolongation (b = 38.77 ms, p = 0.031). For every 1.0 mg/dL increase above the median (0.93 mg/dL), QTc increased 39 ms. Hypertension showed a borderline association with QTc…
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.