Toxic epidermal necrolysis after levofloxacin therapy
Abstract
Abstract: Steven–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is an idiosyncratic, life-threatening adverse drug reaction to many medications, including anticonvulsants, antibiotics, and nonsteroidal anti-inflammatory drugs. It is of immunological origin and manifests as extensive epidermal detachment along with systemic symptoms of fever, malaise, and, in some cases, organ dysfunction. The most common antibiotics implicated in SJS/TEN are beta-lactams, sulfonamides, and fluoroquinolones. There have been a few reports of SJS/TEN with levofloxacin worldwide. We report one such case of a 32-year-old male patient who was referred to our tertiary care center with TEN after being prescribed levofloxacin for a lower respiratory tract infection by a primary health-care physician.
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