Mitochondrial migraine: A multicenter study based on mitochondrial diseases presenting as encephalopathy and/or myopathy
Abstract
Objective: This study aimed to investigate the clinical features of migraine in a cohort of patients with mitochondrial disease (MD) presenting as encephalopathy and/or myopathy, and to explore the potential association between migraine and mitochondrial dysfunction.
Background: MDs comprise a heterogeneous group of disorders characterized by impaired mitochondrial oxidative phosphorylation. The high frequency of migraine among patients with MD presenting as encephalopathy and/or myopathy suggests a potential connection between migraine pathogenesis and mitochondrial dysfunction.
Methods: In this multicenter cross-sectional real-world study, 48 genetically confirmed patients with MD presenting as encephalopathy and/or myopathy were included from seven medical centers in China between January 2020 and March 2023. A structured questionnaire was utilized to collect demographic data, comprehensive clinical information related to MD, and detailed headache information. The frequency, clinical characteristics, and potential factors associated with migraine were analyzed. Furthermore, the frequency and characteristics were compared with data from a population-based survey on primary headaches. According to ICHD-3, the concept of "acute headache preceding or associated with focal neurological deficits and/or seizures (AHF)" was introduced under ICHD-3 6.8.2 Headache attributed to mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). In patients with MELAS,…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 48 participants or records.
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