CGRP and the Trigeminal System in Migraine
Abstract
INTRODUCTION: Calcitonin-gene related peptide (CGRP) is a vasoactive neuropeptide involved in the pathophysiology ofmigraine. CGRP has been targeted for both preventive and acute treatment of migraine.
OBJECTIVE: Provide a summary of the most clinically relevant literature surrounding CGRP modulating therapies.
METHODS: This update on CGRP modulating therapies includes articles selected as most clinically relevant by theauthors.
CONCLUSION: CGRP modulating therapies are an exciting new addition to migraine treatment given their safety andtolerability. Additionally, compared to traditional migraine preventive medication these treatments are migrainespecific.Further real-world and clinical data is ongoing to better understand these treatments that continue to gainfavor in the management of migraine.
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