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Brain Mechanisms of Vagus Nerve Stimulation and Stress Reduction Training for Migraine

ClinicalTrials.gov · COMPLETED, 2025

193 participants

Abstract

This study design has two components: 1) a cross-sectional assessment of brain activity and inflammation in migraine patients compared to healthy controls and 2) an assessment of 8 weeks of a combination therapy approach to treating migraine.

Conditions: Migraine.

Primary outcome: Brain Activity Changes in Migraine Patients in Response to Treatment; Brain Inflammation Changes in Migraine Patients in Response to Treatment.

Enrollment: 193 participants.

How strong is the evidence?

Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 193 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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