Reporting quality and evidence support in randomized controlled trials of herbal medicine formulas for vestibular migraine
Abstract
Background: Vestibular migraine (VM) is a prevalent condition characterized by recurrent episodes of dizziness, vertigo, and/or headache, often posing diagnostic and therapeutic challenges. Numerous randomized controlled trials (RCTs) have highlighted potential benefits of herbal medicine formulas (HMFs) for treating VM. However, current evidence remains insufficient to recommend their routine clinical use. The validity of trial results relies heavily on the completeness of the reporting. Therefore, this study aimed to comprehensively evaluate the reporting quality and evidence support of RCTs investigating HMFs for VM.
Methods: We performed a comprehensive search across eight databases from their inception to August 2024. The included studies were primarily RCTs assessing the effectiveness and safety of HMFs for treating VM. The quality of the RCTs was evaluated using the Consolidated Standards of Reporting Trials (CONSORT) guidelines, along with its extension for Chinese medicine formulas (CONSORT-CHM Formulas). A meta-analysis was conducted to assess the effectiveness and safety of HMFs for the treatment of VM following the Cochrane methodolog. High-frequency herbal medicines (HMs) for VM treatment were identified as those appearing with a cumulative frequency exceeding 50 % among the top-ranked HMs.
Results: A total of 33 RCTs involving 2358 patients with VM were included. The mean score for CONSORT reporting items was 14.24, while the mean score for CONSORT-CHM…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 2,358 participants or records.
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