Prevalence of migraine in individuals with functional seizures: A systematic review and meta-analysis
Abstract
BACKGROUND
This study aimed to understand the prevalence of migraine in patients with functional seizures in general, as well as compared to patients with epileptic seizures.
METHODS
We conducted a literature search of the PubMed, Scopus, and Web of Science databases from database inception until July, 2024. We identified studies using an observational design and performed a meta-analysis to evaluate the association between migraines and functional seizures. We assessed the quality of the studies with the Newcastle-Ottawa Scale, and identified the pooled odds ratios (OR) and mean differences. Heterogeneity was investigated using the I² statistic, significance was determined using Cochran's test, and a post-hoc Begg's test was performed. This study was registered with PROSPERO (CRD42024558536).
RESULTS
Of the 3248 studies identified, 13 studies (N = 2415) were eligible for inclusion. Out of 2415 patients with functional seizures, 763 (31.5 %) patients had comorbid migraine. The pooled OR for prevalence of migraine in individuals with functional seizures compared with those with epileptic seizures was 2.77 (95 % CI: 2.36-3.27), with a corresponding mean difference of 18 % ((95 % CI: 9 %-27 %). Quality assessment revealed moderate-to-high quality in all the included studies.
CONCLUSION
This study revealed a high prevalence of migraine in patients with functional seizures. However, existing evidence is limited to a handful of observational studies. More studies are needed to…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 2,415 participants or records.
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