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Comorbidities as risk factors for migraine onset: A systematic review and three‐level meta‐analysis

Maria Terhart, L. H. Overeem, Jaehwa Hong, Uwe Reuter, Bianca Raffaelli

European Journal of Neurology, 2025

14 citations

Abstract

Migraine is a debilitating neurological disease with a multifaceted pathophysiology. Pre‐existing comorbidities may influence the risk of developing migraine. This review and meta‐analysis aim to present a comprehensive overview of the known comorbidities predisposing individuals to new migraine onset, thereby improving our understanding of the respective diseases' interactions.

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Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.

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