Influence of greater occipital nerve block on the relief of acute migraine: A meta-analysis
Abstract
Background: Greater occipital nerve (GON) block may help relieve acute migraine, and this meta-analysis aimed to investigate the influence of GON block on pain relief of acute migraine. Methods: We systematically searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases, and included randomized controlled trials (RCTs) assessing the efficacy of GON block for acute migraine. Meta-analysis was performed using the random-effect model regardless of the heterogeneity. Results: Four RCTs and 224 patients were included in the meta-analysis. Compared with control intervention in acute migraine, GON block intervention could significantly reduce pain scores at 45 to 60 minutes (MD = −2.31; 95% CI = −3.08 to −1.53; P < .00001) and pain scores at 30 minutes (MD = −1.95; 95% CI = −2.61 to −1.29; P < .00001), but demonstrated no impact on pain scores at 0 to 15 minutes (MD = −0.46; 95% CI = −1.00 to 0.08; P = .09), sustained headache relief (OR = 1.46; 95% CI = 0.06–36.66; P = .82) or rescue medication (OR = 0.32; 95% CI = 0.01–19.16; P = .59). Conclusions: GON block intervention may be able to alleviate pain intensity for acute migraine patients.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 224 participants or records.
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