The Role of Curcumin Supplementation in Patients with Migraine: A Meta-Analysis of Randomized Controlled Trial
Abstract
Objectives: Migraine is a repeated, chronic and neurovascular disease that adversely affects the quality of life and increases the risk of cerebral lesion. Curcumin, the orange-yellow substance of turmeric, may possess anti-headache performance according to several studies. Thus, this study set out to meta-analytically access the anti-headache effect of curcumin supplementation in patients with migraine. Methods: Five databases were searched as of September 30, 2022 to identify all eligible randomized controlled trials. The random-effect Hunter-Schmidt model was used to calculate the effect sizes based on the heterogeneity. The PROSPERO registration number for this meta-analysis is CRD42023409829 (https://www.crd.york.ac.uk/PROSPERO/). Results: Four studies involving 170 patients finally met our inclusion criteria. In the results, curcumin supplementation showed a significant difference in the severity of migraine symptoms compared with placebo (Hedges's g= -0.75, 95% confidence interval (CI) =-1.44 to -0.07, P= 0.03). The results of subgroup analyses indicated that curcumin supplementation was statistically significant in reducing the duration of migraine in patients over 35 years of age (Hedges's g= -0.63, 95%CI= -1.07 to -0.19, P< 0.01) and high-dose curcumin significantly reduced the severity of migraine symptoms (Hedges's g= -1.65, 95%CI= -2.32 to -0.97, P< 0.01). Conclusions: Curcumin supplementation may relieve the severity of headache symptoms in migraine sufferers…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 170 participants or records.
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