Psychological transdiagnostic factors and migraine characteristics as predictors of migraine-related disability
Abstract
BACKGROUND: Migraine is a prevalent primary headache disorder that significantly impairs daily life. Research on factors contributing to migraine-related disability remains limited, particularly from a biopsychosocial perspective. This study investigated whether transdiagnostic psychological factors, as proposed by the Fear Avoidance Model (FAM), contribute to migraine-related disability beyond migraine symptoms.
METHODS: In this cross-sectional analysis of selected baseline data from an ongoing randomized controlled trial, data from N = 158 individuals with migraine reporting ≥ 4 migraine days per month were examined. Data was collected through an online survey, including sociodemographic and clinical characteristics as well as responses to standardized questionnaires (DASS, PCS, FAMI, HIT-6). A hierarchical multiple linear regression analysis was conducted, including independent variables in two blocks: (1) sociodemographic factors and migraine symptoms, and (2) FAM factors (pain catastrophizing, fear of attacks, depressiveness). Disability, the dependent variable, was assessed using the HIT-6 questionnaire. Additionally, mediation analyses were conducted to investigate the potential mediating role of pain catastrophizing in the relationship between pain intensity or attack frequency and disability.
RESULTS: A total of N = 158 participants were included in the analysis. Hierarchical regression analysis showed that sociodemographic and migraine symptoms accounted for 49% of…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 158 participants or records.
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