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Post-traumatic headache phenotypic characteristics and treatment utilization

Nabity PS, McGeary CA, Eapen BC, Houle TT, Resick PA, Moring JC, Reed DE, Jaramillo CA et al.

Cephalalgia : an international journal of headache, 2026

193 participants

Abstract

BackgroundPost-traumatic headache (PTH) is typically described as migraine- or tension-type-like and treated based on presentation. However, the actual presentations of PTH are not well characterized. The aim of this study is to provide a phenotypic characterization of persistent PTH and co-occurring neurological symptoms from a previously completed clinical trial and characterize PTH treatment utilization.MethodsThis study is a secondary analysis of veterans (N = 193) recruited to participate in a randomized clinical trial of cognitive-behavioral therapy, cognitive processing therapy, or treatment as usual for PTH. Descriptive statistics were examined across characteristics of PTH, including age, gender, neurobehavioral symptoms, headache-related disability, pain characteristics, pain locations, accompanying symptoms, and aura symptoms and treatment utilization.ResultsThe median presentation of PTH in this study was a headache with severe pain, lasting about 4 h, and with about 13 headache episodes per month. About half the participants reported a pulsating quality and/or nausea that accompanied head pain. Most characteristics were uncorrelated to each other. The majority of participants used medication to treat persistent PTH. Neurostimulation was the most common non-pharmacological treatment.ConclusionsThe results of this study show that characteristics associated with migraine are more frequently reported with PTH. Correlations among the migraine characteristics were…

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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 193 participants or records.

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