Clinical effect of Xuanyang Jieyu Tongluo Zhitong acupuncture on migraine without aura and its influence on serum neurotransmitter levels
Abstract
Objective: To observe the clinical effect of Xuanyang Jieyu Tongluo Zhitong (clearing yang, relieving liver qi stagnation, promoting collateral circulation and stopping pain) acupuncture on migraine without aura (MwoA) and its influence on serum neurotransmitter levels.
Methods: Sixty patients with MwoA were randomly divided into a meridian-point acupuncture group (acupuncture group, 40 cases) and a meridian-point sham-acupuncture group (sham-acupuncture group, 20 cases) according to the ratio of 2∶1. In the acupuncture group, Xuanyang Jieyu Tongluo Zhitong acupuncture was operated. In the sham-acupuncture group, the needles were not inserted into meridian points. The acupoints in the two groups included Baihui (GV20), and bilateral Fengchi (GB20), Shuaigu (GB8), Yanglingquan (GB34), Kunlun (BL60), Hegu (LI4) and Taichong (LR3). The intervention was delivered once every two days, 3 interventions a week, for consecutive 4 weeks. Before and after treatment, and in follow-up of 12 weeks after treatment completion, the number of headache episodes, headache days, score of visual analogue scale (VAS), score of the six-item headache impact test (HIT-6), and score of migraine specific quality of life questionnaire (MSQ) were observed in the two groups separately. Before and after treatment, the levels of the serum neurotransmitters (5-hydroxytryptamine [5-HT], dopamine [DA], β-endorphin [β-EP], and calcitonin gene-related peptide [CGRP]) were detected in the two groups.
Results:…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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