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Effectiveness of cold application combined with progressive muscle relaxation in migraine without aura: A randomized controlled trial

Kisa EP, Kara Kaya B, Yalman M, Akin AE

Medicine, 2025

26 participants

Abstract

AbstractBackground: Migraine without aura is a prevalent and disabling neurological disorder that significantly impairs quality of life (QoL). This study aimed to evaluate the short-term effectiveness of cold application combined with Jacobson Progressive Muscle Relaxation (JPMR) on pain intensity, migraine frequency, migraine-related disability, and QoL in individuals with migraine without aura. Methods: A randomized controlled trial was conducted with 26 participants diagnosed with migraine without aura. Participants were randomly assigned to 2 groups: group 1 received JPMR exercises and group 2 received JPMR combined with cold application. Pain intensity was assessed using the Visual Analog Scale, disability using the Migraine Disability Assessment questionnaire, and QoL using the World Health Organization Quality of Life Scale-Short Form. Evaluations were conducted at baseline and after a 4-week intervention period. Results: Significant improvements in pain intensity, migraine frequency, disability, and QoL scores were observed in both groups following the intervention (P .05). Conclusion: Both JPMR and JPMR combined with cold application are effective short-term interventions for managing migraine without aura. However, the addition of cold application enhances outcomes in the number of attacks. This combined nonpharmacological approach may be considered as an adjunct strategy for migraine management.

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 26 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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