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Engagement and predictors of use of a smartphone app for migraine self-management: A secondary analysis of the EMMA trial

Lysk S, Pach D, Tissen-Diabaté T, Scholler S, Witt CM

Headache, 2026

238 participants · 2 citations

Abstract

OBJECTIVE: The objective of this secondary analysis was to examine engagement with a mobile app for migraine self-management and to identify predictors of migraine app usage.

BACKGROUND: Migraine self-monitoring and behavioral strategies are central components in migraine self-management, but patient adherence often remains a challenge. Recently, migraine apps have shown promise in enabling more frequent and continuous headache tracking and supporting self-management by integrating behavioral strategies; however, data on patient engagement with these digital interventions are still scarce.

METHODS: This secondary analysis of the EMMA trial used the full dataset of the intervention group, which received a migraine app for 24 weeks, and examined app engagement and factors associated with frequent app usage. Outcomes were frequency of app engagement, intensity of app engagement, and time of usage. Potential associated factors included demographics, migraine history, burden of disease, headache management self-efficacy, and first-week app use. Descriptive analyses summarized engagement patterns for the overall app, the diary, and self-management modules. Kaplan-Meier survival curves illustrated usage over time. Univariable linear regression models explored associations between patient characteristics and first-week app usage as predictors of total app usage.

RESULTS: Of the 238 patients, 161 (67.7%) were still actively using the app after 24 weeks. Total active usage days ranged…

How strong is the evidence?

Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 238 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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