Acute withdrawal and botulinum toxin A in chronic migraine with medication overuse: a double-blind randomized controlled trial
Abstract
Botox is widely used in chronic migraine although efficacy in studies was only modest and likely confounded by unblinding. In a randomised, double-blind, placebo-controlled trial, Pijpers et al. show that Botox affords no additional benefit over acute withdrawal in patients with chronic migraine and medication overuse.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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