Doppler ultrasound studies of the extracranial cerebral vessels in migraine patients after ergotamine tartrate administration
Abstract
Doppler ultrasound investigations were done in 20 patients with migraine during the symptom-free interval after oral administration of 2 mg and 6 mg ergotamine tartrate. The observed changes of end-diastolic flow velocity as a measure of peripheral total resistance permit simultaneous assessment of the vasoconstrictor effect of ergotamine in the perfusion area of the internal and external carotid arteries. A dosage of 2 mg led to an exclusive increase of resistance in the external carotid artery area without significant changes in the internal carotid area. A maximal therapeutic dosage of 6 mg ergotamine tartrate did not lead to a significant increase of the vasoconstrictor effect in the external carotid circulation. In addition, a barely registrable increase of resistance in the internal carotid area could now be observed.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 20 participants or records.
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