Relationship Between Central Sensitization and Genetic Polymorphisms-A Case-Control Study in Fibromyalgia
Abstract
Background: Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Methods: This study included 201 women with fibromyalgia and 40 healthy women matched on age and menopausal status. The nociceptive flexion reflex (NFR) threshold was used as a surrogate marker of CS. Genotyping of 60 candidate-genes likely to influence the pathogenesis of fibromyalgia or chronic pain was explored in all subjects.
Results: The NFR threshold was lower in patients (n = 141, median and [interquartile range]: 34 mA [24-46]) than in controls (n = 35, 58 mA [44-77], p = 0.0003), but none of the tested polymorphism genotype was significant. An association was found between fibromyalgia and three polymorphisms related to TNF, TACR1, and IL10 genes, either by testing the simple allelic frequency or an additive model. When the analysis was adjusted on NFR threshold, only the association with TACR1 was still significant, along with other associations with polymorphisms related to FAAH, HTR1A, and MYT1L. Associations were however non significant when a Bonferroni's correction was applied.
Conclusions: This study confirmed that CS is a major feature of fibromyalgia. Although several polymorphisms stand out in the analysis, no significant relationship between CS and 60 selected candidate-genes genotype…
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 201 participants or records.
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