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NeuroVision training may improve subjective visual quality in patients with residual refractive error after SMILE: a prospective clinical trial

Xu J, Liu M, Liu Q

Frontiers in neuroscience, 2026

Abstract

Objective: To study the improvement of subjective visual quality in patients with a small amount of residual refraction and poor visual quality after small incision ienticule extraction (SMILE) surgery through visual cortex training.

Methods: Eleven subjects (22 eyes) aged 18-40 years who had undergone SMILE >6 months previously were prospectively enrolled. Subjects were trained 30 times, with the pre-training period as the baseline. Untrained patients from the same period were enrolled as controls.

Results: The contrast sensitivity, best corrected visual acuity (BCVA), glare symptoms, and stereoscopic vision of the subjects was improved after training compared with before training. Compared with the eye with poor vision before training, the contrast sensitivity of the eye with good vision before training improved after training. There was no significant change in the no corrected visual acuity (NCVA) and refraction before and after training. After 12 months, contrast sensitivity was better in the visual cortex training group.

Conclusion: For patients with a small amount of residual refractive error and reduced subjective visual quality after SMILE, RevitalVision training improved subjective visual function, particularly contrast sensitivity and related visual performance, without measurable changes in objective optical quality parameters.

Clinical trial registration: Identifier [ChiCTR1800014796].

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Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.

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