The efficacy of alpha‐lipoic acid in improving oxidative, inflammatory, and mood status in women with episodic migraine in a randomised, double‐blind, placebo‐controlled clinical trial
Abstract
Migraine is a common neurovascular disorder, which is associated with severe to moderate disabling headaches. Oxidative stress and inflammation might play a role in migraine pathogenesis and the mood disorders. Considering the antioxidant and anti‐inflammatory properties of alpha‐lipoic acid (ALA), this study was designed to investigate its effect on oxidative, inflammatory, and mood conditions in women with episodic migraine.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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