Cognitive Behavioral Therapy Plus Amitriptyline for Chronic Migraine in Children and Adolescents: A Randomized Clinical Trial
Abstract
BACKGROUND Migraine is ranked in the 2010 Global Burden of Disease Study as the eighth leading cause of years lived with disability There are currently no interventions approved by the FDA for the treatment of chronic migraine in young persons; thus clinical practice is not evidenced based and is quite variable A high priority research need in headache medicine is the testing of multimodal treatments against pharmacotherapy alone
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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