Reduced Serum Uric Acid and Albumin Levels in Patients with Migraine: A Cross-Sectional Study
Abstract
Background/Objectives: Migraine is associated with neurogenic inflammation, trigeminovascular activation, oxidative stress, and systemic metabolic changes. However, circulating antioxidant-related biomarkers in older adults with migraine remain insufficiently characterized. We examined whether self-reported migraine history was associated with serum uric acid (UA), albumin, and total protein levels in the Swedish Adoption/Twin Study of Aging (SATSA), including exploratory analyses in migraine-discordant twin pairs. Methods: This cross-sectional analysis used the first in-person testing wave of SATSA. Participants aged ≥50 years with complete migraine status and biomarker data were included. Serum UA was the primary outcome; albumin and total protein were secondary outcomes. Group differences were assessed using t-tests, Wilcoxon rank-sum tests, or chi-square tests, as appropriate. Linear regression models were adjusted for age, sex, and body mass index. Paired analyses were conducted in 13 migraine-discordant twin pairs. Results: Among 411 participants, 23 reported a migraine history. Participants with migraine had lower serum UA (4.39 vs. 5.15 mg/dL, p = 0.011), albumin (4.40 vs. 4.55 g/dL, p = 0.019), and total protein (7.16 vs. 7.43 g/dL, p = 0.008). These associations remained significant after adjustment. In discordant twin pairs, UA was lower in twins with migraine than in co-twins without migraine (4.34 vs. 4.72 mg/dL, p = 0.050), whereas albumin and total protein…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 411 participants or records.
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